After 25 years in a tiny clinic, the team are moving to a brand new clinic with twice the space to help animals in need. When Dr. Jeff repairs a dog's knee, he makes a special connection with her owner.
When a beloved dog is hit by a car, Dr. Jeff battles to save his shattered leg. Then Dr. Amy takes on a new challenge treating 7 bad-tempered chickens. And a tiny kitten found unconscious at a construction site unites everyone in a fight to save it.
Houston welcomes veterinarians Dr. Blue, Dr. Ross and Dr. Lavigne, who have their hands full with everything from risky surgeries to diagnosing sick chameleons. A car accident brings the practice to a halt as one of the doctors faces a long recovery.
Dr. Ross buys a mobile unit for community outreach and Dr. Blue enlists his brother to help deck it out. Back at the clinic, Dr. Ross examines an iguana for an abscess and Dr. Lavigne helps a paraplegic dachshund get a new set of wheels.
Dr. Dee swaps roles as she takes her own dog to a specialist in Anchorage for eye surgery. There, she reconnects with her step-daughter to check on a barrel racing horse. Meanwhile, a remote clinic takes a turn for the worse for Dr. Terry and Nicole.